Brain peroxisomes
نویسندگان
چکیده
منابع مشابه
Peroxisomes in brain development and function☆
Peroxisomes contain numerous enzymatic activities that are important for mammalian physiology. Patients lacking either all peroxisomal functions or a single enzyme or transporter function typically develop severe neurological deficits, which originate from aberrant development of the brain, demyelination and loss of axonal integrity, neuroinflammation or other neurodegenerative processes. Whils...
متن کاملSeeing peroxisomes
Seeing peroxisomes t about the same time that Christian de Duve and his colleagues were describing the biochemistry of lysosomes (see “Catching sight of lysosomes” JCB 168: 174), they biochemically identified (Baudhuin et al., 1965) and purified (Leighton et al., 1968) another enzyme-containing organelle. Initially the organelle was known as the microbody, and de Duve declined to give it a more...
متن کاملPartial disassembly of peroxisomes
Rat liver peroxisomes were subjected to a variety of procedures intended to partially disassemble or damage them; the effects were analyzed by recentrifugation into sucrose gradients, enzyme analyses, electron microscopy, and SDS PAGE. Freezing and thawing or mild sonication released some matrix proteins and produced apparently intact peroxisomal "ghosts" with crystalloid cores and some fuzzy f...
متن کاملHow proteins penetrate peroxisomes
Three decades after the unobtrusive debut of the peroxisome as a distinct subcellular organelle, biologists are paying attention to the special bag of tricks eukaryotic cells use to entice peroxisomal proteins from their site of synthesis in the cytosol to the peroxisome. In this minireview, we highlight some of the recent findings that have emerged, emphasize their significance, and contrast t...
متن کاملPeroxisomes and oxidative stress.
The discovery of the colocalization of catalase with H2O2-generating oxidases in peroxisomes was the first indication of their involvement in the metabolism of oxygen metabolites. In past decades it has been revealed that peroxisomes participate not only in the generation of reactive oxygen species (ROS) with grave consequences for cell fate such as malignant degeneration but also in cell rescu...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2014
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2013.09.009